What is Semaglutide and How Does It Work?
Semaglutide is an FDA-approved medication that has shown significant effectiveness in weight management. It works as a synthetic version of a hormone called glucagon-like peptide-1 (GLP-1), which your body naturally produces in the intestines.
When administered, Semaglutide:
Targets areas of the brain that regulate appetite and food intake, helping you feel fuller for longer periods
Slows down stomach emptying, which contributes to reduced hunger and prolonged satiety
Improves insulin sensitivity, allowing your body to more efficiently burn calories and fat
Helps reduce cravings, particularly for high-calorie foods
Works gradually in the body to support sustainable weight loss when combined with lifestyle modifications
Many patients report not only weight loss but also improvements in related health markers such as blood pressure, cholesterol levels, and blood sugar control.
Common Side Effects
The most common side effects experienced by patients include:
Nausea (typically mild to moderate and often improving over time)
Diarrhea (usually temporary as your body adjusts to the medication)
Less Common Side Effects
Vomiting
Constipation
Abdominal pain
Headache
Fatigue
Upset stomach
Dizziness
Bloating
Belching and gas
Gastroenteritis (stomach flu)
Heartburn
Upper respiratory symptoms (runny nose, sore throat)
Rare Side Effects
Burning sensation in the chest or stomach
Indigestion
Stomach upset
Tenderness in the stomach area
Most side effects are mild to moderate and tend to decrease over time as your body adjusts to the medication. Proper hydration, eating smaller meals, and avoiding high-fat foods can help minimize digestive side effects.
Medical Warnings
Risk of thyroid C-cell tumors: Semaglutide has caused thyroid C-cell tumors in rodent studies (relevance to humans is currently unknown)
Acute pancreatitis: Discontinue if pancreatitis is suspected
Acute gallbladder disease: May increase the risk for gallstones
Hypoglycemia: Can cause low blood sugar, especially if used with other diabetes medications
Allergic reactions: Ranging from mild to severe; seek immediate medical attention for severe reactions
Diabetic retinopathy: Monitor vision changes, especially in patients with diabetes
Increased heart rate: May cause elevated heart rate, particularly in patients with cardiac conditions
Suicidal behavior and ideation: Monitor for mood changes or depressive symptoms
Contraindications
Semaglutide should not be used in the following cases:
Pregnancy: Not recommended (classified as Pregnancy Category C)
Breastfeeding: Effects unknown; discuss with your healthcare provider
Pediatric patients: Not approved for patients under 12 years of age
Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
Previous serious allergic reaction to Semaglutide
Always discuss your complete medical history and list of medications with your healthcare provider before starting Semaglutide treatment.
For patients self-administering injections at home:
Store in refrigerator between 36°F to 46°F (2°C to 8°C)
Do not freeze the medication
Keep away from direct sunlight
Keep all medications out of reach of children and pets
Dispose of used needles properly in a sharps container
For detailed instructions on how to properly administer Semaglutide:
Our staff will give you an injection guide pamphlet (downloadable here) with step-by-step instructions
Ask our nursing staff for assistance if you're unsure about the injection technique
Consider using a reminder app to maintain your regular dosing schedule
Follow the recommended dose escalation schedule as prescribed
To get the most benefit from your Semaglutide treatment:
Follow a balanced, nutritious diet as recommended by your healthcare provider
Engage in regular physical activity appropriate for your fitness level
Keep all follow-up appointments to monitor your progress
Report any concerning side effects promptly
Stay well-hydrated throughout your treatment
Keep a journal of your weight, measurements, and how you're feeling
Be patient – optimal results typically develop over several months of consistent treatment
We're committed to supporting your optimal health journey. Please contact our office with any questions or concerns about your Semaglutide treatment.
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All our laparoscopic procedures are performed by our highly trained surgical team using state-of-the-art equipment and techniques.
We're committed to providing you with the most advanced, minimally invasive options because we believe you deserve:
Less pain after surgery
Shorter hospital stays
Faster return to work and activities you enjoy
Smaller, less visible scars
Lower risk of complications
Better overall outcomes
Dr. Richard Nguyen is a board-certified General Surgeon with over 20 years of surgical expertise and fellowship training in Minimally Invasive and Bariatric Surgery from Vanderbilt University. Since establishing his practice in San Jose in 2007, he has pioneered innovative surgical techniques, including single-incision laparoscopic procedures and mastery of the da Vinci Robotic Surgical System. Beyond his acclaimed bariatric surgery practice, he has earned national recognition for his specialized expertise in both non-mesh and advanced mesh hernia repairs, while also serving as a critical approach surgeon for anterior spine access procedures. Dr. Nguyen combines technical precision with personalized care across multiple premier facilities throughout the South Bay Area.
I would refer Doctor Nguyen to anyone, in fact I have and they have all had the same experience as me. He is truly great. I owe all my success to Doctor Nguyen and I thank him for all the work he has done for me and continues to do so. He is extremely amazing, and I am very grateful to him.
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At 50, I now have a life I had only dreamed of a year before. My body tells me if I am done eating. This surgery is a tool that I have used to the fullest. It is not an easy way out. It still took work. But I honestly know that I would not be living this amazing new life if I didn’t step forward to embrace this life-saving surgery.
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Dr. Nguyen has changed my life completely. I feel so much better and I also feel like I’ve got control of my life again…I had high blood pressure, diabetes and cholesterol. I took at least 5 different medications for the past 30 years. NOW, after surgery I take no medications only vitamins!
Wondering which weight loss medication might be right for your body type? We're here to help you understand your treatment options and develop a personalized plan with either Semaglutide or Tirzepatide.
Contact our office today to schedule a consultation.Your path to sustainable weight loss may be more achievable than you think—with advanced pharmaceutical therapies leading to consistent results, minimal side effects, and a significantly enhanced relationship with food and your body.